Aciclovir 30 60 90 tabs 200mg Atsigerpin Zovirax Viroleks Geviran Cold Sore

Aciclovir 30 tablets 200mg per pack.

Synonyms

Atsigerpin, Valtrex, Viroleks, Geviran, Herpevir, Gerperaks, Zovirax, Medovir

Pharmacotherapeutic group

Antiviral (antiherpetic) facility.

Composition

1 tablet contains 200 mg of acyclovir.

ATC code: J05AB01.


Pharmacological action
Pharmacodynamics
Acyclovir is active against herpes simplex virus (Herpes simplex) types 1 and 2, herpes zoster (Varicella zoster), and Epstein-Barr virus. Less sensitive to the effects of acyclovir cytomegalovirus. Molecular biological mechanism of the antiviral activity of acyclovir due to the competitive interaction of the viral thymidine kinase phosphorylation and consistent with the formation of mono-, di-and triphosphate. Acyclovir triphosphate in place of deoxyguanosine incorporated into viral DNA, inhibits DNA polymerase and inhibits the last replication. Herpes acyclovir prevents the formation of new elements of the rash, reduces the likelihood of cutaneous dissemination and visceral complications, promotes the formation of crusts. Helps reduce pain in the acute phase of herpes zoster. Acyclovir for shingles.

Pharmacokinetics
When administered independently from the meal, absorbed about 20 % of the acyclovir. Binding to plasma proteins is relatively low ( 9-33 %). Concentration in cerebrospinal fluid is approximately 50 % of the plasma concentration. The maximum concentration is determined by the half-life of 1.5-2 hours acyclovir ingestion of about 4 hours. Mainly kidneys intact, partially (10-15 %) as a metabolite - 9 carboxymethoxy methylguanine. In renal insufficiency, the half-life is greatly increased (up to 19.5 hours). Acyclovir penetrates the blood-brain and placental barriers, excreted in breast milk.

Indications for use
0.2 g of acyclovir tablets used in the primary and recurrent infections of the skin and mucous membranes caused by the herpes simplex virus types 1 or 2 (including genital herpes, and rectal) for the prevention of infections of the skin and mucous membranes caused by the herpes simplex virus 1 or 2 types in patients with immune system disorders, for the treatment of infections caused by viruses of herpes zoster, varicella-zoster virus.

Dosing and dosing regimen
The drug is taken by mouth, drinking plenty of water.
To treat infections of the skin and mucous membranes, caused by herpes simplex viruses , administered 1 tablet (0.2 g ) 5 times a day (except for the night). For the prevention of infections of the skin and mucous membranes caused by the herpes simplex viruses in patients with impaired immune systems, designate an adult to 1 tablet (0.2 g) 4 times a day.

For the treatment of infections caused by a herpes zoster virus , administered 4 tablets (0.8 g ), 4-5 times a day.
When administered rectal HSV infection: 2 tablets (0.4 g ) 5 times a day for 10 days.
When genital herpes appoint 1 tablet ( 0.2 g ) 5 times a day to prevent recurrent genital herpes infections - 2-5 times a day for 5 days.
Children under the age of two years, to appoint half the adult dose for children older than 2 years is prescribed in doses for adults.
The duration of treatment is usually 5 days. With infections caused by the herpes zoster virus , the treatment was continued for 3 days after the disappearance of the disease.
Prophylactic treatment with organ transplants carried out within 6 weeks.
Use of the drug is not recommended in neonates.
Cautions
Treatment is recommended to start with the appearance of the earliest signs of the disease.
Side effect
When taking the drug orally may headache, fatigue, neurological disorders, nausea, vomiting, diarrhea, increased serum levels of bilirubin, urea and creatinine, transient elevation of liver transaminases. Possible allergic skin reactions, fever, edema, lymphadenopathy.

Contraindications
Hypersensitivity to acyclovir. Restricted to receive the drug are pregnancy and lactation (at the time of treatment should stop breastfeeding). Precautionary measures
To prevent crystallization in tubular apparatus is recommended to take plenty of fluids during the treatment period . Interaction with other drugs
Probenecid slows excretion of acyclovir (blocks tubular secretion).
Overdose
Symptoms. Headache, neurological disorders, shortness of breath, nausea, vomiting, diarrhea, renal failure, lethargy, convulsions, coma. Treatment. Maintaining vital functions, hemodialysis.

Each tablet contains 200 mg of acyclovir

Aciclovir tabs 200 mg.




Suppressive treatment

Active against herpes simplex virus (Herpes simplex) types 1 and 2.

Acyclovir ointment 5 % (50mg/g)

Aciclovir 5g tube 5% Cream generic.



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Aciclovir is used for treating varicella (chickenpox), herpes zoster (shingles) and genital herpes infections.

Aciclovir (Aciclovirum) is a medicine specially designed for the treatment of of infections caused by the virus Herpes simplex. Aciclovir is usually prescribed for treating varicella, herpes zoster, genital herpes infections and even to HIV-Infected Adult Patients. There are other brand names for Aciclovir, such as Zovirax and Acyclovir.

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